Developmental Cancer Genomics
Taking apart childhood cancer bit by bit
We are a team of computational and experimental biologists at St. Anna Children's Cancer Research Institute (CCRI). It is our goal to understand how genetic changes disrupt cellular development and cause diseases like cancer. By employing an integrative approach that combines stem cell biology with functional genomics, we strive to ultimately prevent these diseases.
We trace (aberrant) changes in cells during development.
Background: Hematopoiesis, immunity, and cancer
We map regulatory networks that shape cell identity.
Background: Stem cell transcription factors
We develop tools that connect pieces of data into knowledge.
Background: Wet- and dry-lab tools and resources
Nat. Methods 2012 ; Nat. Biotechnol. 2016 ; Cell Stem Cell 2018
Our research currently focuses on understanding and modulating the earliest effects of cancer-linked mutations on development, tumorigenicity, and plasticity in embryonal tumors.
Commun. Biol. 2025 ; Nat. Commun. 2024a ; Nat. Commun. 2024b ; Nucleic Acids Res. 2026
📰 Check out our latest pre-print: Pasajlic, Plaschka, et al.
ℹ️ Find out more about our research here! Do you have the know-how, creativity, and passion to join the quest? We'd like to hear from you!