We are a team of computational and experimental biologists at St. Anna Children's Cancer Research Institute (CCRI). It is our goal to understand developmental processes in cancer biology by employing an integrative approach that combines stem cell biology with functional genomics.
We trace (aberrant) changes in cells during development.
We map regulatory networks that shape cell identity.
We develop tools that connect pieces of data into knowledge.
Our research currently focuses on understanding and modulating the earliest effects of cancer-linked mutations on development, tumorigenicity, and plasticity in embryonal tumors and other childhood cancers.
To this end, we use stem cell organoids and other experimental models and genomics technologies. Commun. Biol. 2025; Nat. Commun. 2024a; Nat. Commun. 2024b; bioRxiv 2025
Check out our latest pre-prints: Montano, Mueller, et al. and Suresh, Hafemeister, et al.
Find out more about our research here! Do you have the know-how, creativity, and passion to join the quest? We'd like to hear from you!
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